Marcellus Ubbink | Protein Chemistry

Marcellus Ubbink, Prof. Dr.

Position:

Head of Department, Professor of Protein Chemistry

Expertise:

Protein interactions (Ubbink group)

Telephone number: +31 (0)71 527 4628
E-mail address: m.ubbink@chem.leidenuniv.nl
Faculty/Unit: Faculty of Science, Leiden Institute of Chemistry, Protein Chemistry
Office address: Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber L117

ResearcherID

2012

Liu, W.M., Keizers, P.H.J., Hass, M.A.S., Blok, A., Timmer, M., Sarris, A.J.C., Overhand, M., Ubbink, M. , A pH-Sensitive, Colorful, Lanthanide-Chelating Paramagnetic NMR Probe, Journal of the American Chemical Society, vol. 134, no. 41, pp. 17306-17313. DOI

Lindfors, H.E., Drijfhout, J.W., Ubbink, M. , The Src SH2 domain interacts dynamically with the focal adhesion kinase binding site as demonstrated by paramagnetic nmr spectroscopy, IUBMB Life, vol. 64, no. 6, pp. 538-544. DOI

Scanu, S., Forster, J., Finiguerra, M.G., Shabestari, M.H., Huber, M., Ubbink, M. , The Complex of Cytochrome f and Plastocyanin from Nostoc sp PCC 7119 is Highly Dynamic, ChemBioChem, vol. 13, no. 9, pp. 1312-1318. DOI

Ubbink, M. , Dynamics in transient complexes of redox proteins, Biochemical Society Transactions, vol. 40, pp. 415-418. DOI

Keizers, P.H.J., Hiruma, Y., Ubbink, M. , Protein-Paramagnetic Protein Interactions, NMR of Biomolecules.Towards Mechanistic Systems Biology: Wiley-Blackwell, pp. 204-217.

Schilder, J.T., Hass, M.A.S., Keizers, P.H.J., Ubbink, M. , Paramagnetic NMR Spectroscopy and Lowly Populated States, Recent Developments in Biomolecular NMR: The Royal Society of Chemistry, pp. 130-150.

2011

Meschi, F., Wiertz, F., Klauss, L., Blok, A., Ludwig, B., Merli, A., Heering, H.A., Rossi, G.L., Ubbink, M. , Efficient Electron Transfer in a Protein Network Lacking Specific Interactions, Journal of the American Chemical Society, vol. 133, no. 42, pp. 16861-16867. DOI

Dasgupta, S., Hu, X.Y., Keizers, P.H.J., Liu, W.M., Luchinat, C., Nagulapalli, M., Overhand, M., Parigi, G., Sgheri, L., Ubbink, M. , Narrowing the conformational space sampled by two-domain proteins with paramagnetic probes in both domains, Journal of Biomolecular Nmr, vol. 51, no. 3, pp. 253-263. DOI

Bashir, Q., Scanu, S., Ubbink, M. , Dynamics in electron transfer protein complexes, Febs Journal, vol. 278, no. 9, pp. 1391-1400. DOI

Alagaratnam, S., Meeuwenoord, N.J., Navarro, J.A., Hervas, M., De la Rosa, M.A., Hoffmann, M., Einsle, O., Ubbink, M., Canters, G.W. , Probing the reactivity of different forms of azurin by flavin photoreduction, Febs Journal, vol. 278, no. 9, pp. 1506-1521. DOI

Lindfors, H.E., Venkata, B.S., Drijfhout, J.W., Ubbink, M. , Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains, Febs Letters, vol. 585, no. 4, pp. 601-605. DOI

Keizers, P.M., Ubbink, M. , Paramagnetic tagging for protein structure and dynamics analysis, Progress in Nuclear Magnetic Resonance Spectroscopy, vol. 58, no. 1-2, pp. 88-96. DOI

Volkov, A.N., Barrios, H., Mathonet, P., Evrard, C., Ubbink, M., Declercq, J.P., Soumillion, P., Fastrez, J. , Engineering an Allosteric Binding Site for Aminoglycosides into TEM1-beta-Lactamase, Chembiochem, vol. 12, no. 6, pp. 904-913. DOI

Keizers, P.H.J., Ubbink, M. , Paramagnetic tools in protein NMR, Protein NMR spectroscopy: Practical Techniques and applications: Wiley, Chichester, pp. 193-220.

2010

Xu, X.F., Scanu, S., Chung, J.S., Hirasawa, M., Knaff, D.B., Ubbink, M. , Structural and Functional Characterization of the Ga-Substituted Ferredoxin from Synechocystis sp PCC6803, a Mimic of the Native Protein, Biochemistry, vol. 49, no. 36, pp. 7790-7797. DOI

Meschi, F., Wiertz, F., Klauss, L., Cavalieri, C., Blok, A., Ludwig, B., Heering, H.A., Merli, A., Rossi, G.L., Ubbink, M. , Amicyanin Transfers Electrons from Methylamine Dehydrogenase to Cytochrome c-551i via a Ping-Pong Mechanism, not a Ternary Complex, Journal of the American Chemical Society, vol. 132, no. 41, pp. 14537-14545. DOI

Hass, M.A.S., Keizers, P.H.J., Blok, A., Hiruma, Y., Ubbink, M. , Validation of a Lanthanide Tag for the Analysis of Protein Dynamics by Paramagnetic NMR Spectroscopy, Journal of the American Chemical Society, vol. 132, no. 29, pp. 9952-9953. DOI

Bashir, Q., Volkov, A.N., Ullmann, G.M., Ubbink, M. , Visualization of the Encounter Ensemble of the Transient Electron Transfer Complex of Cytochrome c and Cytochrome c Peroxidase, Journal of the American Chemical Society, vol. 132, no. 1, pp. 241-247. DOI

Volkov, A.N., Ubbink, M., van Nuland, N.A.J. , Mapping the encounter state of a transient protein complex by PRE NMR spectroscopy, Journal of Biomolecular Nmr, vol. 48, no. 4, pp. 225-236. DOI

Keizers, P.H.J., Mersinli, B., Reinle, W., Donauer, J., Hiruma, Y., Hannemann, F., Overhand, M., Bernhardt, R., Ubbink, M. , A Solution Model of the Complex Formed by Adrenodoxin and Adrenodoxin Reductase Determined by Paramagnetic NMR Spectroscopy, Biochemistry, vol. 49, no. 32, pp. 6846-6855. DOI

Volkov, A.N., Bashir, Q., Worrall, J.A.R., Ullmann, G.M., Ubbink, M. , Shifting the Equilibrium between the Encounter State and the Specific Form of a Protein Complex by Interfacial Point Mutations, Journal of the American Chemical Society, vol. 132, no. 33, pp. 11487-11495. DOI

Impagliazzo, A., Tepper, A.W., Verrips, T.C., Ubbink, M., van der Maarel, S.M. , Structural basis for a PABPN1 aggregation-preventing antibody fragment in OPMD, Febs Letters, vol. 584, no. 8, pp. 1558-1564. DOI

2009

Cavalieri, C., Biermann, N., Vlasie, M.D., Einsle, O., Merli, A., Ferrari, D., Rossi, G.L., Ubbink, M. , Structural Comparison of Crystal and Solution States of the 138 kDa Complex of Methylamine Dehydrogenase and Amicyanin from Paracoccus versutus (vol 47, pg 6560, 2008), Biochemistry, vol. 48, no. 18, pp. 4008-4008. DOI

Takahashi, I, Kuroiwa, S., Lindfors, H.E., Ndamba, L.A., Hiruma, Y., Yajima, T., Okishio, N., Ubbink, M., Hirota, S. , Modulation of protein-ligand interactions by photocleavage of a cyclic peptide using phosphatidylinositol 3-kinase SH3 domain as model system, Journal of Peptide Science, vol. 15, no. 6, pp. 411-416. DOI

Keizers, P., Mersinli, B., Reinle, W., Hiruma, Y., Hannemann, F., Bernhardt, R., Overhand, M., Ubbink, M. , The adrenodoxin redox chain protein complexes studied by paramagnetic NMR, Febs Journal, vol. 276, pp. 144-144.

Marcellus Ubbink teaches or supervises the following courses:

Marcellus currently supervises the following students:

28/09/2012

Protein Chemistry

Marcellus Ubbink, Prof. Dr.

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